The overarching idea of the BelBi 2018 Conference is to illuminate different aspects of bioinformation systems, including theoretical approaches in modeling different phenomena in life sciences, information technologies necessary for analysis and understanding huge amount of generated data, application of computer science and informatics in precision medicine, microbiology, and plant science, search for novel remedies against debilitating diseases and drug development, and other similar topics. The BelBi 2018 conference will address three topics concerning theoretical approaches to bioinformation systems, bioinformatics and data mining for OMICs data, and biomedical informatics