The 17th conference on Computational Methods in Systems Biology (CMSB 2019) will take place from 18th to 20th September 2019 in Trieste, Italy. Its aim is to bring together researchers from across biological, mathematical, computational, and physical sciences who are interested in the study, modelling, simulation, advanced analysis, and design of biological systems. CMSB 2019 will be hosted at the University of Trieste, Italy.