The conference aims to increase the awareness and interest around main aspects and address controversial questions about Huntington’s Disease, a genetic disabling disorder. One of the largest databases in the world is dedicated to the disease, so the knowledge about clinical phenotypes is going into progressive increase, thanks to a huge number of clinicians and researchers around the world. Nowadays, novel disease-modifying treatments are under human experimentation, and they could represent the possible starting of a new era in HD management.