The ECN2020 conference follows on from the hugely successful inaugural ECN2019, which took place in London, UK in April 2019. We have received a wealth of positive feedback from the speakers and the attendees at ECN2019 and we will again strive to facilitate investigative and analytical discussion of a range of neurodegenerative diseases. The focus will be on multiple sclerosis as a paradigmatic neuroinflammatory and neurodegenerative disease but we will also have talks on neuromyelitis optica and Alzheimer’s disease to allow for cross-fertilizing discussions.