The third edition of the Protein Engineering Canada (PEC) Conference will be held at the University of British Columbia (Vancouver, Canada) between June 17-20, 2018. The goals of the PEC Conference are to bring together leading experts in protein engineering, evolution and design, and structural and synthetic biology, to present their latest findings and develop a strong network throughout Canada and abroad. By creating an engaging atmosphere for innovative discussions, we aim to promote collaborations among protein engineers and create productive opportunities for young investigators to present their work and exchange ideas with leaders in the field.