Organ-on-a-Chip is of keen interest to many scientists working in translational sciences. Whilst the technology is still in its infancy, Organ-on-a-Chip is expected to deliver game changing solutions and progressively increase our capacity to gain greater insight into mechanisms of human disease, toxicity and early efficacy assessment of new therapies. There are many Organ-on-a-Chip start-ups that have developed within academic institutions and are now attracting interest and financial investment. This conference will review where the current state of the art is and where the bottle necks and future directions lay.